Title Age-related Sexual Dimorphism in Temporal Discrimination and in Adult-onset Dystonia Suggests GABAergic Mechanisms
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Some rights reserved. For more information, please see the item record link above. Title Age-related Sexual Dimorphism in Temporal Discrimination and in Adult-onset Dystonia Suggests GABAergic Mechanisms Author(s) Butler, John S.; Beiser, Ines M.; Williams, Laura; McGovern, Eavan; O'Riordan, Sean; Hutchinson, Michael; et al. Publication date 2015-12 Publication information Frontiers in Neurology, 6 (258): 1-8
منابع مشابه
Age-Related Sexual Dimorphism in Temporal Discrimination and in Adult-Onset Dystonia Suggests GABAergic Mechanisms
BACKGROUND Adult-onset isolated focal dystonia (AOIFD) presenting in early adult life is more frequent in men, whereas in middle age it is female predominant. Temporal discrimination, an endophenotype of adult-onset idiopathic isolated focal dystonia, shows evidence of sexual dimorphism in healthy participants. OBJECTIVES We assessed the distinctive features of age-related sexual dimorphism o...
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Temporal discrimination is the ability to determine that two sequential sensory stimuli are separated in time. For any individual, the temporal discrimination threshold (TDT) is the minimum interval at which paired sequential stimuli are perceived as being asynchronous; this can be assessed, with high test-retest and inter-rater reliability, using a simple psychophysical test. Temporal discrimi...
متن کاملYoung Women do it Better: Sexual Dimorphism in Temporal Discrimination
The temporal discrimination threshold (TDT) is the shortest time interval at which two sensory stimuli presented sequentially are detected as asynchronous by the observer. TDTs are known to increase with age. Having previously observed shorter thresholds in young women than in men, in this work we sought to systematically examine the effect of sex and age on temporal discrimination. The aims of...
متن کاملA Headset Method for Measuring the Visual Temporal Discrimination Threshold in Cervical Dystonia
BACKGROUND The visual temporal discrimination threshold (TDT) is the shortest time interval at which one can determine two stimuli to be asynchronous and meets criteria for a valid endophenotype in adult-onset idiopathic focal dystonia, a poorly penetrant disorder. Temporal discrimination is assessed in the hospital laboratory; in unaffected relatives of multiplex adult-onset dystonia patients ...
متن کاملTemporal discrimination threshold: VBM evidence for an endophenotype in adult onset primary torsion dystonia.
Familial adult-onset primary torsion dystonia is an autosomal dominant disorder with markedly reduced penetrance. Most adult-onset primary torsion dystonia patients are sporadic cases. Disordered sensory processing is found in adult-onset primary torsion dystonia patients; if also present in their unaffected relatives this abnormality may indicate non-manifesting gene carriage. Temporal discrim...
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تاریخ انتشار 2017